Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 8/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.53 |
| ▸ | SMPD3 | Q9NY59 | 9/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20119347 | 0.76 | GSK3B (0.45) | PIK3CGPIK3CAIRAK4 | |
| SCHEMBL20119135 | 0.75 | SMPD3 (0.56) | SMPD3 | |
| SCHEMBL21313078 | 0.75 | NTRK1 (0.72) | — | |
| SCHEMBL20119462 | 0.72 | SMPD3 (0.56) | SMPD3 | |
| SCHEMBL21319482 | 0.72 | SMPD3 (0.52) | SMPD3 | |
| SCHEMBL21319488 | 0.70 | SMPD3 (0.50) | SMPD3IRAK4 | |
| SCHEMBL18968044 | 0.69 | SMPD3 (1.00) | SMPD3 | |
| SCHEMBL20119340 | 0.69 | SMPD3 (0.51) | SMPD3 | |
| SCHEMBL20119441 | 0.69 | SMPD3 (0.51) | SMPD3IRAK4 | |
| SCHEMBL31259868 | 0.68 | SMPD3 (1.00) | SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3533796-B1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| EP-3533796-A1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2019-09-04 | — | — | EP | disclosed |
| WO-2018077246-A1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | 正大天晴药业集团股份有限公司 | 2018-05-03 | — | — | WO | disclosed |