Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 15/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20119122 | 0.87 | SMPD3 (0.51) | SMPD3IRAK4ALDH1A1GAA | |
| SCHEMBL21319640 | 0.87 | SMPD3 (0.59) | SMPD3IRAK4CSF1RMETSRC | |
| SCHEMBL23865295 | 0.87 | SMPD3 (0.51) | SMPD3IRAK4ALDH1A1GAA | |
| SCHEMBL20119620 | 0.81 | SMPD3 (0.48) | SMPD3IRAK4NTRK1 | |
| SCHEMBL20119411 | 0.79 | SMPD3 (0.43) | SMPD3IRAK4 | |
| SCHEMBL20119364 | 0.79 | SMPD3 (0.43) | SMPD3IRAK4 | |
| SCHEMBL23633777 | 0.76 | SMPD3 (0.50) | SMPD3IRAK4NTRK1 | |
| SCHEMBL20119929 | 0.75 | SMPD3 (0.42) | SMPD3IRAK4MAP4K4 | |
| SCHEMBL22175153 | 0.74 | SMPD3 (0.74) | SMPD3 | |
| SCHEMBL20119928 | 0.73 | MAPT (0.45) | SMPD3IRAK4ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018077246-A1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | 正大天晴药业集团股份有限公司 | 2018-05-03 | — | — | WO | disclosed |