Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 11/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23865295 | 1.00 | SMPD3 (0.51) | SMPD3KDM4EALDH1A1GAAJAK2 | |
| SCHEMBL20119481 | 0.87 | SMPD3 (0.43) | SMPD3ALDH1A1GAAIRAK4 | |
| SCHEMBL21319640 | 0.86 | SMPD3 (0.59) | SMPD3ALDH1A1IRAK4 | |
| SCHEMBL20119489 | 0.82 | SMPD3 (0.54) | SMPD3JAK2JAK3PRKDCIRAK4 | |
| SCHEMBL21319573 | 0.80 | SMPD3 (0.52) | SMPD3JAK2JAK3PRKDCIRAK4 | |
| SCHEMBL21319519 | 0.80 | SMPD3 (0.52) | SMPD3JAK2JAK3PRKDCIRAK4 | |
| SCHEMBL21319518 | 0.74 | SIGMAR1 (0.36) | SMPD3KDM4EALDH1A1GAAIRAK4 | |
| SCHEMBL20119928 | 0.74 | MAPT (0.45) | SMPD3ALDH1A1IRAK4 | |
| SCHEMBL19560117 | 0.72 | SMPD3 (0.62) | SMPD3IRAK4 | |
| SCHEMBL21319568 | 0.71 | SMPD3 (0.50) | SMPD3JAK2JAK3IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3533796-A1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2019-09-04 | — | — | EP | disclosed |
| WO-2018077246-A1 | AMINO PYRAZOLOPYRIMIDINE COMPOUND USED AS NEUROTROPHIC FACTOR TYROSINE KINASE RECEPTOR INHIBITOR | 正大天晴药业集团股份有限公司 | 2018-05-03 | — | — | WO | disclosed |