Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 10/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20119182 | 0.85 | HDAC6 (0.46) | HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL20173798 | 0.82 | HDAC6 (0.44) | HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL10120332 | 0.82 | HDAC6 (0.62) | HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL10120344 | 0.77 | HDAC6 (0.56) | HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL20178641 | 0.75 | ALDH1A1 (0.51) | HDAC6HDAC8ITGB3ITGA2B | |
| SCHEMBL10120339 | 0.75 | HDAC6 (0.64) | HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL20178679 | 0.74 | ACACB (0.59) | HDAC6HDAC8PRMT5WDR77 | |
| SCHEMBL10120343 | 0.74 | HDAC6 (0.63) | HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL10120349 | 0.74 | HDAC6 (0.59) | HDAC6HDAC8HDAC1HDAC3 | |
| SCHEMBL10104761 | 0.72 | HDAC6 (0.57) | HDAC6HDAC8PRMT5WDR77HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081285-A1 | UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |