Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 15/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23932000 | 0.88 | HCAR3 (0.41) | NTRK1NTRK3NTRK2MKNK1KDM4E | |
| SCHEMBL15254587 | 0.85 | MKNK1 (0.44) | NTRK1NTRK3NTRK2MKNK1KDM4E | |
| SCHEMBL30217989 | 0.83 | IKBKB (0.36) | NTRK1NTRK3NTRK2MKNK1GBA1 | |
| SCHEMBL16371971 | 0.81 | NTRK1 (0.60) | NTRK1NTRK3NTRK2MKNK1KDM4E | |
| SCHEMBL15258024 | 0.81 | MKNK1 (0.43) | NTRK1NTRK3NTRK2MKNK1GBA1 | |
| SCHEMBL16468193 | 0.77 | NTRK1 (0.47) | NTRK1NTRK3NTRK2MKNK1GBA1 | |
| SCHEMBL16468273 | 0.76 | NTRK1 (0.46) | NTRK1NTRK3NTRK2MKNK1KDM4E | |
| SCHEMBL16468487 | 0.76 | NTRK1 (0.46) | NTRK1NTRK3NTRK2MKNK1KDM4E | |
| SCHEMBL16468589 | 0.74 | NTRK1 (0.36) | NTRK1NTRK3NTRK2MKNK1KDM4E | |
| SCHEMBL23932182 | 0.74 | MKNK1 (0.36) | MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822559-B1 | IMIDAZO[1,2-B]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | LEXICON PHARMACEUTICALS INC (US) | 2018-05-02 | — | — | EP | disclosed |