SCHEMBL20119880

SCHEMBL20119880

COc1cc(-c2cc(C)c(N)c(C)c2)ccn1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.48
ALDH1A1 P00352 1/20 0.48
TP53 P04637 1/20 0.48
TSHR P16473 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
LOX P28300 1/20 0.46
LOXL2 Q9Y4K0 1/20 0.46
S1PR1 P21453 2/20 0.44
DYRK1A Q13627 4/20 0.44
AAK1 Q2M2I8 5/20 0.41
LRRK2 Q5S007 1/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
NOS3 P29474 1/20 0.41
NOS1 P29475 1/20 0.41
NOS2 P35228 1/20 0.41
KMT2A Q03164 1/20 0.41
ACVR2A P27037 3/20 0.40
TGFBR2 P37173 3/20 0.40
TGFBR1 P36897 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18471249 0.86 S1PR1 (0.46) CYP3A4LOXLOXL2S1PR1DYRK1A
SCHEMBL16116782 0.83 LOX (0.55) LOXLOXL2S1PR1DYRK1AAAK1
SCHEMBL30626327 0.83 LOX (0.55) LOXLOXL2S1PR1DYRK1AAAK1
SCHEMBL30531646 0.83 S1PR1 (0.47) LOXLOXL2S1PR1DYRK1AAAK1
SCHEMBL15261990 0.83 S1PR1 (0.47) LOXLOXL2S1PR1DYRK1AAAK1
SCHEMBL18481804 0.82 LOX (0.47) LOXLOXL2S1PR1DYRK1AAAK1
SCHEMBL30531656 0.79 LRRK2 (0.44) LOXLOXL2S1PR1DYRK1ALRRK2
SCHEMBL15344107 0.79 CNR1 (0.50) LOXLOXL2S1PR1DYRK1ALRRK2
SCHEMBL12441340 0.78 DYRK1A (0.65) LOXLOXL2S1PR1DYRK1AAAK1
SCHEMBL13036116 0.78 DYRK1A (0.55) LOXLOXL2S1PR1DYRK1AAAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3532458-B1 BENZYLAMINOPYRIDYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF BOEHRINGER INGELHEIM INT (DE) 2021-01-20 EP disclosed
WO-2018138027-A1 BENZYLAMINOPYRIDYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICALCOMPOSITIONS AND USES THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2018-08-02 WO disclosed
WO-2018138028-A1 BENZYLAMINOPYRAZINYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2018-08-02 WO disclosed
WO-2018138026-A1 INDANYLAMINOPYRAZINYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2018-08-02 WO disclosed
WO-2018095877-A1 INDANYLAMINOPYRIDYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2018-05-31 WO disclosed
WO-2018077699-A1 BENZYLAMINOPYRIDYLCYCLOPROPANECARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2018-05-03 WO disclosed