Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.42 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20119953 | 0.83 | AAK1 (0.59) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL15254438 | 0.80 | AAK1 (0.48) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL15254978 | 0.80 | AAK1 (0.52) | AAK1RET | |
| SCHEMBL15254435 | 0.79 | AAK1 (0.49) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL19494399 | 0.78 | DYRK3 (0.61) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL15258059 | 0.76 | AAK1 (0.62) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL20120004 | 0.76 | AAK1 (0.56) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL19466750 | 0.76 | AAK1 (0.62) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL19467077 | 0.74 | AAK1 (0.57) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL19466875 | 0.74 | AAK1 (0.60) | DYRK1ADYRK3CCNT1CDK9DYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822559-B1 | IMIDAZO[1,2-B]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | LEXICON PHARMACEUTICALS INC (US) | 2018-05-02 | — | — | EP | disclosed |