Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.53 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.53 |
| ▸ | CHRNA6 | Q15825 | 2/20 | 0.53 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15258056 | 1.00 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| SCHEMBL18768737 | 1.00 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| Hydrochloric Acid SCHEMBL15254877 | 0.98 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| Hydrochloric Acid SCHEMBL15254876 | 0.98 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| SCHEMBL18700542 | 0.81 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| SCHEMBL15249475 | 0.81 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| SCHEMBL19687189 | 0.80 | CHRNB2 (0.49) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| SCHEMBL30546694 | 0.79 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| SCHEMBL12414501 | 0.78 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 | |
| SCHEMBL19869622 | 0.78 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNA3CHRNB3CHRNA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822559-B1 | IMIDAZO[1,2-B]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | LEXICON PHARMACEUTICALS INC (US) | 2018-05-02 | — | — | EP | disclosed |