Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20120159 | 0.90 | TP53 (0.49) | TP53MAPTPOLBLMNATHRB | |
| SCHEMBL20120048 | 0.87 | TP53 (0.53) | TP53MAPTPOLBLMNATHRB | |
| SCHEMBL20120131 | 0.86 | TP53 (0.50) | TP53MAPTPOLBLMNAAHR | |
| SCHEMBL20113811 | 0.86 | TP53 (0.64) | TP53MAPTPOLBLMNATHRB | |
| SCHEMBL20120053 | 0.83 | TP53 (0.47) | TP53MAPTPOLBLMNATHRB | |
| SCHEMBL20113814 | 0.83 | TP53 (0.73) | TP53MAPTPOLBLMNATHRB | |
| SCHEMBL20120157 | 0.82 | MAPT (0.47) | TP53MAPTPOLBLMNA | |
| SCHEMBL20120057 | 0.82 | TP53 (0.54) | TP53MAPTPOLBLMNATHRB | |
| SCHEMBL20120155 | 0.81 | TP53 (0.47) | TP53MAPTPOLBLMNATHRB | |
| SCHEMBL20114216 | 0.81 | TP53 (0.59) | TP53MAPTPOLBLMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081378-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |