Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | FPR1 | P21462 | 6/20 | 0.39 |
| ▸ | FPR2 | P25090 | 3/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20120053 | 0.87 | TP53 (0.47) | MAPTTP53LMNAPOLB | |
| SCHEMBL21259980 | 0.84 | MAPT (0.51) | MAPTTP53LMNAPOLBFPR1 | |
| SCHEMBL20120048 | 0.83 | TP53 (0.53) | MAPTTP53LMNAPOLB | |
| SCHEMBL20113831 | 0.83 | TP53 (0.56) | MAPTTP53LMNAPOLBFPR1 | |
| SCHEMBL21245466 | 0.83 | MAPT (0.48) | MAPTTP53LMNAPOLBFPR1 | |
| SCHEMBL21245463 | 0.82 | MAPT (0.51) | MAPTTP53LMNAPOLBFPR1 | |
| SCHEMBL20113946 | 0.82 | MAPT (0.47) | MAPTTP53LMNAPOLBFPR1 | |
| SCHEMBL20120050 | 0.82 | TP53 (0.51) | MAPTTP53LMNAPOLB | |
| SCHEMBL20113811 | 0.80 | TP53 (0.64) | MAPTTP53LMNAPOLB | |
| SCHEMBL20120159 | 0.80 | TP53 (0.49) | MAPTTP53LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190248779-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. | 2019-08-15 | — | — | US | disclosed |
| US-20190248779-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. | 2019-08-15 | — | — | US | disclosed |
| WO-2018081378-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2018-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190248779-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY | CFTR, SCNN1B, SCNN1G | MAPT 4790/4885TP53 1387/4885LMNA 1626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.