Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24074245 | 0.82 | HTT (0.51) | HPGDHSD17B10KDM4EMAPTGAA | |
| SCHEMBL12411738 | 0.82 | HTT (0.47) | HPGDHSD17B10KDM4EMAPTGAA | |
| SCHEMBL13111002 | 0.81 | KDM4E (0.56) | HPGDHSD17B10KDM4EMAPTDYRK1A | |
| SCHEMBL15254918 | 0.81 | MAPT (0.40) | HPGDHSD17B10KDM4EMAPTDYRK1A | |
| SCHEMBL26582556 | 0.81 | HTT (0.50) | HPGDHSD17B10KDM4EMAPTGAA | |
| SCHEMBL15258058 | 0.80 | AKR1C3 (0.47) | HPGDHSD17B10KDM4EMAPTDYRK1A | |
| SCHEMBL20119749 | 0.80 | DYRK1A (0.51) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL12613670 | 0.80 | MAPT (0.43) | HPGDHSD17B10KDM4EMAPTAPAF1 | |
| SCHEMBL15254681 | 0.78 | CSNK1E (0.46) | HSD17B10KDM4EDYRK1ADYRK3CCNT1 | |
| SCHEMBL1055595 | 0.78 | ALOX15 (0.51) | HPGDHSD17B10KDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822559-B1 | IMIDAZO[1,2-B]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | LEXICON PHARMACEUTICALS INC (US) | 2018-05-02 | — | — | EP | disclosed |