Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.52 |
| ▸ | FYN | P06241 | 11/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15255002 | 0.81 | AAK1 (0.53) | AAK1FYNJAK1EGLN1 | |
| SCHEMBL15258054 | 0.81 | AAK1 (0.53) | AAK1FYNJAK1EGLN1 | |
| SCHEMBL20120142 | 0.77 | AAK1 (0.60) | AAK1FYNRIPK2 | |
| SCHEMBL15254778 | 0.74 | AAK1 (0.54) | AAK1FYNJAK1 | |
| SCHEMBL15254782 | 0.74 | AAK1 (0.54) | AAK1FYNJAK1 | |
| SCHEMBL19467068 | 0.69 | AAK1 (0.57) | AAK1FYN | |
| SCHEMBL19467098 | 0.69 | AAK1 (0.82) | AAK1FYNEGLN1 | |
| SCHEMBL19467099 | 0.68 | AAK1 (0.56) | AAK1FYN | |
| SCHEMBL19467100 | 0.68 | AAK1 (0.63) | AAK1FYNJAK1 | |
| SCHEMBL16010419 | 0.67 | FYN (0.70) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822559-B1 | IMIDAZO[1,2-B]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | LEXICON PHARMACEUTICALS INC (US) | 2018-05-02 | — | — | EP | disclosed |