Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.60 |
| ▸ | FYN | P06241 | 10/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19467068 | 0.86 | AAK1 (0.57) | AAK1FYNPOLBMAPTALDH1A1 | |
| SCHEMBL20119956 | 0.86 | AAK1 (0.56) | AAK1FYNMAPTDYRK3CCNT1 | |
| SCHEMBL19467099 | 0.85 | AAK1 (0.56) | AAK1FYNPOLBMAPTALDH1A1 | |
| SCHEMBL15254866 | 0.82 | AAK1 (0.59) | AAK1FYNPOLBMAPTALDH1A1 | |
| SCHEMBL19466884 | 0.82 | AAK1 (0.67) | AAK1FYNPOLBMAPTUSP2 | |
| SCHEMBL19467154 | 0.81 | AAK1 (0.59) | AAK1FYNPOLBMAPTUSP2 | |
| Hydrochloric Acid SCHEMBL15254901 | 0.81 | AAK1 (0.59) | AAK1FYNPOLBMAPTALDH1A1 | |
| SCHEMBL20119749 | 0.80 | DYRK1A (0.51) | FYNDYRK3CCNT1CDK9DYRK1A | |
| SCHEMBL20120084 | 0.77 | AAK1 (0.52) | AAK1FYNRIPK2 | |
| SCHEMBL19467098 | 0.76 | AAK1 (0.82) | AAK1FYNITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822559-B1 | IMIDAZO[1,2-B]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | LEXICON PHARMACEUTICALS INC (US) | 2018-05-02 | — | — | EP | disclosed |