Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
| ▸ | HRH2 | P25021 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13994323 | 1.00 | MAPK1 (0.53) | MAPK1ALDH1A1LMNAKMT2AMEN1 | |
| Valeric Acid SCHEMBL27839056 | 0.89 | HRH2 (0.52) | MAPK1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL1706174 | 0.88 | MAPK1 (0.55) | MAPK1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL1706172 | 0.88 | MAPK1 (0.55) | MAPK1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL12535753 | 0.88 | MAPK1 (0.55) | MAPK1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL7352660 | 0.86 | MAPK1 (0.54) | MAPK1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL22591021 | 0.84 | CTSK (0.60) | MAPK1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL19853291 | 0.84 | CTSK (0.60) | MAPK1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL8307745 | 0.84 | CTSK (0.60) | MAPK1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL29990568 | 0.84 | TSHR (0.41) | MAPK1ALDH1A1LMNAKMT2ACTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822559-B1 | IMIDAZO[1,2-B]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | LEXICON PHARMACEUTICALS INC (US) | 2018-05-02 | — | — | EP | disclosed |