Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 12/20 | 0.62 |
| ▸ | TMIGD3 | P0DMS9 | 9/20 | 0.59 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18353050 | 1.00 | ADORA3 (0.62) | ADORA3TMIGD3HTR2BSLC6A3ADORA1 | |
| SCHEMBL20121269 | 0.92 | ADORA3 (0.73) | ADORA3TMIGD3HTR2BSLC6A3ADORA1 | |
| SCHEMBL18352999 | 0.92 | ADORA3 (0.73) | ADORA3TMIGD3HTR2BSLC6A3ADORA1 | |
| SCHEMBL20121270 | 0.89 | ADORA3 (0.73) | ADORA3TMIGD3HTR2BSLC6A3ADORA1 | |
| SCHEMBL18353051 | 0.89 | ADORA3 (0.73) | ADORA3TMIGD3HTR2BSLC6A3ADORA1 | |
| SCHEMBL18352568 | 0.86 | ADORA3 (0.72) | ADORA3TMIGD3SLC6A3ADORA1OPRD1 | |
| SCHEMBL20122142 | 0.84 | ADORA3 (0.86) | ADORA3TMIGD3HTR2BSLC6A3ADORA1 | |
| SCHEMBL16774192 | 0.84 | ADORA3 (0.86) | ADORA3TMIGD3HTR2BSLC6A3ADORA1 | |
| SCHEMBL18352619 | 0.83 | ADORA3 (0.87) | ADORA3TMIGD3HTR2BSLC6A3ADORA1 | |
| SCHEMBL18352471 | 0.80 | TMIGD3 (0.73) | ADORA3TMIGD3SLC6A3ADORA1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963450-B2 | A3 adenosine receptor agonists | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2018-05-08 | — | — | US | disclosed |