Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SAE1 | Q9UBE0 | 20/20 | 0.53 |
| ▸ | UBA2 | Q9UBT2 | 20/20 | 0.53 |
| ▸ | NAE1 | Q13564 | 14/20 | 0.53 |
| ▸ | UBA3 | Q8TBC4 | 14/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17410433 | 0.86 | SAE1 (0.68) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL17429075 | 0.86 | SAE1 (0.58) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL21205351 | 0.82 | SAE1 (0.53) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL21128965 | 0.78 | SAE1 (0.48) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL17410355 | 0.77 | SAE1 (0.64) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL22446213 | 0.77 | SAE1 (0.60) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL17421667 | 0.75 | SAE1 (0.76) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL17429072 | 0.74 | SAE1 (0.44) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL17429074 | 0.74 | SAE1 (0.43) | SAE1UBA2NAE1UBA3 | |
| SCHEMBL17410046 | 0.74 | SAE1 (0.78) | SAE1UBA2NAE1UBA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9962386-B2 | Heteroaryl compounds useful as inhibitors of SUMO activating enzyme | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2018-05-08 | — | — | US | disclosed |