Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 15/20 | 0.68 |
| ▸ | RXRB | P28702 | 9/20 | 0.68 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.68 |
| ▸ | CYP26B1 | Q9NR63 | 5/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | RXRG | P48443 | 7/20 | 0.51 |
| ▸ | RARB | P10826 | 4/20 | 0.39 |
| ▸ | RARG | P13631 | 3/20 | 0.39 |
| ▸ | RARA | P10276 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17911588 | 0.86 | RXRA (0.67) | RXRARXRBCYP26A1CYP26B1CYP3A4 | |
| SCHEMBL13368672 | 0.82 | CYP26A1 (0.70) | RXRARXRBCYP26A1CYP26B1CYP3A4 | |
| SCHEMBL30218800 | 0.81 | RXRA (1.00) | RXRARXRBCYP26A1CYP26B1CYP3A4 | |
| SCHEMBL2807932 | 0.81 | RXRA (1.00) | RXRARXRBCYP26A1CYP26B1CYP3A4 | |
| Ammonia Solution, Strong SCHEMBL8706692 | 0.80 | RXRA (0.97) | RXRARXRBCYP26A1CYP26B1CYP3A4 | |
| Ammonia Solution, Strong SCHEMBL8706695 | 0.80 | RXRA (0.97) | RXRARXRBCYP26A1CYP26B1CYP3A4 | |
| SCHEMBL15908233 | 0.79 | MAOB (0.40) | RXRARXRBCYP26A1CYP26B1CYP3A4 | |
| SCHEMBL8608030 | 0.78 | RXRA (0.75) | RXRARXRBCYP26A1CYP26B1CYP3A4 | |
| SCHEMBL30011660 | 0.76 | RXRA (1.00) | RXRARXRBCYP26A1CYP26B1CYP3A4 | |
| SCHEMBL7463646 | 0.76 | RXRA (1.00) | RXRARXRBCYP26A1CYP26B1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044216-B1 | NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2022-02-23 | — | — | EP | disclosed |
| US-9963439-B2 | Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2018-05-08 | — | — | US | disclosed |