SCHEMBL20122027

SCHEMBL20122027

COc1ccc(-c2ccc(/C=C/C(=O)OCc3ccccc3)cc2)cc1C1(C)CC2CC(C)CC(C2)C1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC11 Q96DB2 4/20 0.52
HDAC2 Q92769 1/20 0.52
CA12 O43570 2/20 0.50
CA4 P22748 2/20 0.50
CA6 P23280 2/20 0.50
CA5A P35218 2/20 0.50
CA7 P43166 2/20 0.50
CA9 Q16790 2/20 0.50
CA14 Q9ULX7 2/20 0.50
CA5B Q9Y2D0 2/20 0.50
HDAC1 Q13547 1/20 0.49
HDAC7 Q8WUI4 1/20 0.49
HDAC8 Q9BY41 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
AKR1B10 O60218 2/20 0.45
AKR1B1 P15121 2/20 0.45
LMNA P02545 3/20 0.45
TTR P02766 4/20 0.43
MAPT P10636 3/20 0.43
ALDH1A1 P00352 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17914350 0.89 HDAC11 (0.67) HDAC11HDAC2CA12CA4CA6
SCHEMBL29566969 0.89 HDAC11 (0.67) HDAC11HDAC2CA12CA4CA6
SCHEMBL20122013 0.86 HDAC11 (0.61) HDAC11HDAC2CA12CA4CA6
SCHEMBL30175038 0.80 HDAC11 (0.55) HDAC11HDAC2CA12CA4CA6
SCHEMBL17914354 0.78 HDAC11 (0.54) HDAC11HDAC2CA12CA4CA6
SCHEMBL29567185 0.78 HDAC11 (0.54) HDAC11HDAC2CA12CA4CA6
SCHEMBL17916351 0.74 HDAC11 (0.48) HDAC11HDAC2HDAC1HDAC7HDAC8
SCHEMBL20121991 0.74 HDAC11 (0.48) HDAC11HDAC2CA12CA4CA6
SCHEMBL405445 0.74 HDAC11 (0.82) HDAC11HDAC2HDAC1HDAC7HDAC8
SCHEMBL405444 0.74 HDAC11 (0.82) HDAC11HDAC2HDAC1HDAC7HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9963439-B2 Specific inhibitors of cytochrome P450 26 retinoic acid hydroxylase UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) 2018-05-08 US disclosed