Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3923901 | 0.98 | MAPT (0.42) | MAPTSMN1; SMN2ELANEALOX15THRB | |
| SCHEMBL3925033 | 0.92 | TLR8 (0.40) | MAPTSMN1; SMN2ELANEALOX15SIRT2 | |
| SCHEMBL3922006 | 0.83 | TLR8 (0.37) | MAPTSMN1; SMN2ALOX15STSALDH1A1 | |
| SCHEMBL11717767 | 0.75 | TTR (0.57) | ELANEALOX15EPHX2PPARAALDH1A1 | |
| SCHEMBL11719258 | 0.75 | TTR (0.57) | ELANEALOX15EPHX2PPARAALDH1A1 | |
| SCHEMBL183395 | 0.73 | — | — | |
| SCHEMBL17895868 | 0.73 | CYP4F2 (0.48) | MAPTSMN1; SMN2ELANEALOX15PTGS2 | |
| SCHEMBL11715954 | 0.73 | TTR (0.58) | MAPTELANEALOX15EPHX2PPARA | |
| SCHEMBL11723061 | 0.72 | KDM4E (0.50) | MAPTELANEALDH1A1TSHRHTT | |
| SCHEMBL30889343 | 0.72 | MAPT (0.45) | MAPTSMN1; SMN2ELANEALOX15PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963450-B2 | A3 adenosine receptor agonists | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2018-05-08 | — | — | US | disclosed |