SCHEMBL20122334

SCHEMBL20122334

CC(C)(C)OC(=O)/N=C(/NCCOc1ccc(COS(C)(=O)=O)c(COS(C)(=O)=O)c1)NC(=O)OC(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CA1 P00915 7/20 0.44
CA2 P00918 7/20 0.44
CA12 O43570 5/20 0.44
CA9 Q16790 5/20 0.44
PDK2 Q15119 1/20 0.38
IDO1 P14902 2/20 0.34
BCHE P06276 1/20 0.34
CNR2 P34972 1/20 0.34
PTGS2 P35354 1/20 0.33
GRIN1 Q05586 1/20 0.32
GRIN2B Q13224 1/20 0.32
ITGB3 P05106 1/20 0.32
ITGA2B P08514 1/20 0.32
NQO2 P16083 1/20 0.32
SUCNR1 Q9BXA5 1/20 0.32
MAPT P10636 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16504502 0.87 CA12 (0.58) CA1CA2CA12CA9PDK2
SCHEMBL20122336 0.84 CA12 (0.44) CA1CA2CA12CA9PDK2
SCHEMBL21386653 0.78 CA12 (0.44) CA1CA2CA12CA9PDK2
SCHEMBL24669294 0.78 CA12 (0.53) CA1CA2CA12CA9PDK2
SCHEMBL24671341 0.77 CA12 (0.49) CA1CA2CA12CA9PDK2
SCHEMBL29802513 0.74 CA12 (0.51) CA1CA2CA12CA9PTGS2
SCHEMBL24834412 0.74 CA12 (0.51) CA1CA2CA12CA9PTGS2
SCHEMBL15125597 0.73 POLB (0.46) CA1CA2CA12CA9PDK2
SCHEMBL16504793 0.73 CA12 (0.36) CA1CA2CA12CA9PDK2
SCHEMBL20122293 0.73 HDAC4 (0.40) CA1CA2CA12CA9ITGB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9963427-B2 Dithiol mucolytic agents PARION SCIENCES, INC. (US) 2018-05-08 US disclosed