Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.58 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.58 |
| ▸ | PYGL | P06737 | 5/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052696 | 0.91 | HCRTR1 (0.59) | HCRTR1HCRTR2PYGLATMNPC1 | |
| SCHEMBL2015645 | 0.91 | HCRTR1 (0.59) | HCRTR1HCRTR2PYGLATMNPC1 | |
| SCHEMBL2015054 | 0.89 | HCRTR1 (0.60) | HCRTR1HCRTR2PYGLNPC1RAB9A | |
| SCHEMBL13139095 | 0.84 | HCRTR1 (0.70) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL13139101 | 0.81 | HCRTR1 (0.66) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL2012507 | 0.81 | HCRTR1 (0.68) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL2053280 | 0.81 | HCRTR1 (0.68) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL13139060 | 0.80 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL2012515 | 0.79 | HCRTR1 (0.65) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL13139076 | 0.79 | HCRTR1 (0.70) | HCRTR1HCRTR2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |