Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.65 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.38 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012583 | 0.87 | HCRTR1 (0.64) | HCRTR1HCRTR2NPC1RAB9ACTNNB1 | |
| SCHEMBL2014120 | 0.85 | HCRTR1 (0.68) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2017845 | 0.85 | HCRTR1 (0.68) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2010943 | 0.85 | HCRTR1 (0.66) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL13139060 | 0.85 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2010961 | 0.84 | HCRTR1 (0.64) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2015169 | 0.83 | HCRTR1 (0.65) | HCRTR1HCRTR2NPC1RAB9AMAPK14 | |
| SCHEMBL2011913 | 0.83 | HCRTR1 (0.45) | HCRTR1HCRTR2NPC1RAB9AMAPK14 | |
| SCHEMBL2011909 | 0.83 | HCRTR1 (0.45) | HCRTR1HCRTR2NPC1RAB9AMAPK14 | |
| SCHEMBL2013785 | 0.83 | HCRTR1 (0.67) | HCRTR1HCRTR2NPC1RAB9APADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |