Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | HRH2 | P25021 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR1E | P28566 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29235094 | 0.86 | NPC1 (0.61) | NPC1RAB9AL3MBTL1HTR2CSMN1; SMN2 | |
| SCHEMBL25697440 | 0.84 | NPC1 (0.51) | NPC1RAB9AL3MBTL1TMEM97SIGMAR1 | |
| SCHEMBL2539997 | 0.82 | NPC1 (0.67) | NPC1RAB9AL3MBTL1HTR2CSMN1; SMN2 | |
| SCHEMBL16425133 | 0.81 | NPC1 (0.55) | NPC1RAB9AL3MBTL1TMEM97SIGMAR1 | |
| SCHEMBL29218649 | 0.80 | ALDH1A1 (0.45) | NPC1RAB9AL3MBTL1TMEM97SIGMAR1 | |
| SCHEMBL520065 | 0.79 | NPC1 (0.59) | NPC1RAB9AL3MBTL1TMEM97SIGMAR1 | |
| SCHEMBL17736 | 0.79 | MEN1 (0.49) | NPC1RAB9AL3MBTL1TMEM97SIGMAR1 | |
| SCHEMBL2851491 | 0.79 | SMN1; SMN2 (0.57) | NPC1RAB9ATMEM97SIGMAR1HTR2C | |
| SCHEMBL24673292 | 0.79 | MEN1 (0.66) | NPC1RAB9AL3MBTL1TMEM97SIGMAR1 | |
| SCHEMBL2607031 | 0.79 | MEN1 (0.66) | NPC1RAB9AL3MBTL1TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186232-B1 | P38 MAP KINASE INHIBITING INDANYL UREA COMPOUNDS | TORRENT PHARMACEUTICALS LTD (IN) | 2019-03-27 | — | — | EP | disclosed |
| US-9963463-B2 | Urea-substituted indanes as P38 map kinase inhibitors | TORRENT PHARMACEUTICALS LIMITED (IN) | 2018-05-08 | — | — | US | disclosed |