Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 7/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.32 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17816262 | 0.85 | KDM5B (0.38) | PIM1AXLKDREPHB4TEK | |
| SCHEMBL17816457 | 0.76 | PIM1 (0.41) | PIM1AXLBAZ2BBAZ2A | |
| SCHEMBL21695575 | 0.67 | JAK2 (0.41) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL19538827 | 0.65 | AXL (0.62) | PIM1AXL | |
| SCHEMBL16701134 | 0.65 | AXL (0.42) | PIM1AXLKDREPHB4TEK | |
| SCHEMBL19176085 | 0.65 | JAK2 (0.35) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL19000359 | 0.65 | HRH4 (0.33) | — | |
| SCHEMBL26242520 | 0.64 | PIM1 (0.39) | PIM1AXLKDREPHB4TEK | |
| SCHEMBL15074148 | 0.64 | AXL (0.48) | PIM1AXLPIK3CAPIK3CG | |
| SCHEMBL16561261 | 0.63 | JAK2 (0.44) | JAK2JAK1TYK2JAK3PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963445-B2 | Chemical compounds | SYNGENTA LIMITED (GB) | 2018-05-08 | — | — | US | disclosed |