Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 8/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16561353 | 0.73 | PIM1 (0.38) | PIM1AXLADORA2ABRD4LRRK2 | |
| SCHEMBL14983673 | 0.73 | SIGMAR1 (0.44) | PIM1AXLLRRK2SIGMAR1 | |
| SCHEMBL17816457 | 0.73 | PIM1 (0.41) | PIM1AXLADORA2ALRRK2AURKA | |
| SCHEMBL24713133 | 0.70 | LRRK2 (0.44) | PIM1AXLBRD4LRRK2AURKA | |
| SCHEMBL16701022 | 0.70 | PIM1 (0.42) | PIM1AXLADORA2ALRRK2KDR | |
| SCHEMBL17816262 | 0.68 | KDM5B (0.38) | PIM1AXLLRRK2KDREPHB4 | |
| SCHEMBL16701134 | 0.68 | AXL (0.42) | PIM1AXLADORA2ABRD4DYRK1A | |
| SCHEMBL22344901 | 0.67 | PIM1 (0.37) | PIM1AXLPLAUEPHX2MAPK1 | |
| SCHEMBL12668067 | 0.67 | KDM4E (0.41) | BRD4MAPK1 | |
| SCHEMBL16320327 | 0.67 | SIGMAR1 (0.42) | PIM1AXLBRD4LRRK2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150201-A2 | SODIUM CHANNEL BLOCKING COMPOUNDS, DERIVATIVES THEREOF, AND METHODS OF THEIR USE | LATIGO BIOTHERAPEUTICS, INC. (US) | 2023-08-10 | — | — | WO | disclosed |