Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | SLC34A1 | Q06495 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30664200 | 0.92 | KCNH2 (0.49) | DYRK1AKCNH2PTGER4ROCK2NFATC1 | |
| SCHEMBL20122885 | 0.92 | KCNH2 (0.49) | DYRK1AKCNH2PTGER4ROCK2NFATC1 | |
| SCHEMBL30664155 | 0.86 | ROCK2 (0.45) | DYRK1AKCNH2PTGER4ROCK2NFATC1 | |
| SCHEMBL20122876 | 0.86 | ROCK2 (0.45) | DYRK1AKCNH2PTGER4ROCK2NFATC1 | |
| SCHEMBL20122914 | 0.85 | ROCK2 (0.39) | DYRK1AKCNH2PTGER4ROCK2NFATC1 | |
| SCHEMBL30664289 | 0.85 | ROCK2 (0.39) | DYRK1AKCNH2PTGER4ROCK2NFATC1 | |
| SCHEMBL30664172 | 0.85 | DYRK1A (0.45) | DYRK1AKCNH2PTGER4ROCK2NFATC1 | |
| SCHEMBL20123075 | 0.85 | DYRK1A (0.45) | DYRK1AKCNH2PTGER4ROCK2NFATC1 | |
| SCHEMBL30664277 | 0.82 | KCNH2 (0.39) | DYRK1AKCNH2PTGER4ROCK2NFATC1 | |
| SCHEMBL20123069 | 0.82 | KCNH2 (0.39) | DYRK1AKCNH2PTGER4ROCK2NFATC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3792262-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2021-03-17 | — | — | EP | disclosed |
| EP-3318563-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2018-05-09 | — | — | EP | disclosed |