Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.31 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20122923 | 0.90 | DYRK1A (0.34) | DYRK1ALRRK2 | |
| SCHEMBL30664271 | 0.84 | PRPS1 (0.43) | DYRK1AHASPINDYRK2AAK1LRRK2 | |
| SCHEMBL20122882 | 0.84 | PRPS1 (0.43) | DYRK1AHASPINDYRK2AAK1LRRK2 | |
| SCHEMBL20122758 | 0.82 | PDK2 (0.42) | DYRK1AHASPINDYRK2 | |
| SCHEMBL30664313 | 0.81 | CREBBP (0.43) | DYRK1A | |
| SCHEMBL20122973 | 0.81 | CREBBP (0.43) | DYRK1A | |
| SCHEMBL30664285 | 0.80 | DYRK1A (0.41) | DYRK1AHASPINDYRK2AAK1LRRK2 | |
| SCHEMBL20122935 | 0.80 | DYRK1A (0.41) | DYRK1AHASPINDYRK2AAK1LRRK2 | |
| SCHEMBL20123058 | 0.80 | DYRK1A (0.36) | DYRK1AHASPINDYRK2AAK1LRRK2 | |
| SCHEMBL20122990 | 0.79 | CREBBP (0.42) | DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3792262-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2021-03-17 | — | — | EP | disclosed |
| EP-3318563-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2018-05-09 | — | — | EP | disclosed |