Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20123029 | 0.72 | MAPT (0.53) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL21044375 | 0.64 | ALDH1A1 (0.54) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL29817530 | 0.63 | MAPT (1.00) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL27893270 | 0.63 | MAPT (1.00) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL30663714 | 0.63 | DYRK1A (0.62) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL21384050 | 0.63 | DYRK1A (0.62) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL2213731 | 0.62 | HDAC1 (0.70) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL15383825 | 0.61 | ALDH1A1 (0.49) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL29227283 | 0.61 | MAPT (0.71) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL28073839 | 0.61 | MAPT (0.71) | MAPTALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3318563-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2018-05-09 | — | — | EP | disclosed |