Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 4/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 6/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | CHUK | O15111 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30664216 | 0.89 | CRHR1 (0.37) | CYP17A1DYRK1AHASPINDYRK2ACHE | |
| SCHEMBL22474564 | 0.89 | CRHR1 (0.37) | CYP17A1DYRK1AHASPINDYRK2ACHE | |
| SCHEMBL30664207 | 0.74 | CRHR1 (0.42) | — | |
| SCHEMBL20122950 | 0.74 | CRHR1 (0.42) | — | |
| SCHEMBL30664292 | 0.73 | BRD4 (0.37) | DYRK1AHASPINDYRK2ACHEMAOA | |
| SCHEMBL20122937 | 0.73 | BRD4 (0.37) | DYRK1AHASPINDYRK2ACHEMAOA | |
| SCHEMBL20123079 | 0.72 | HDAC1 (0.35) | DYRK1AHASPINDYRK2ACHE | |
| SCHEMBL30664229 | 0.72 | HDAC1 (0.35) | DYRK1AHASPINDYRK2ACHE | |
| SCHEMBL20123005 | 0.72 | DYRK1A (0.44) | DYRK1AHASPINDYRK2ACHEMAOA | |
| SCHEMBL30664291 | 0.72 | DYRK1A (0.44) | DYRK1AHASPINDYRK2ACHEMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3792262-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2021-03-17 | — | — | EP | disclosed |
| EP-3318563-A1 | SUBSTITUTED PYRIDO[3,4-B]INDOLES FOR THE TREATMENT OF CARTILAGE DISORDERS | SANOFI (FR) | 2018-05-09 | — | — | EP | disclosed |