Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | KDM6A | O15550 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | RGS12 | O14924 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10446735 | 0.84 | HTT (0.39) | ALDH1A1HTTAPPHRH3 | |
| SCHEMBL4316207 | 0.83 | HDAC3 (0.43) | — | |
| SCHEMBL10446100 | 0.81 | PARP1 (0.36) | — | |
| SCHEMBL4331050 | 0.80 | COMT (0.43) | KDM4EHTTSMN1; SMN2 | |
| SCHEMBL20014605 | 0.78 | COMT (0.31) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL4320121 | 0.76 | ERCC1 (0.48) | KDM4EALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL4315216 | 0.76 | CYP2D6 (0.47) | KDM4ECYP2C9CYP2C19KMT2AMEN1 | |
| SCHEMBL12997887 | 0.75 | KDM4E (0.42) | KDM4EKDM6AKDM4ACYP2C9CYP2C19 | |
| SCHEMBL4153042 | 0.75 | RAB9A (0.46) | ALDH1A1KMT2AMEN1NPC1LMNA | |
| SCHEMBL4330995 | 0.73 | ERCC1 (0.42) | KDM4ECYP2C9CYP2C19ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2620436-B1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO (JP) | 2018-05-09 | — | — | EP | disclosed |