Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12066598 | 0.85 | LMNA (0.46) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL7458840 | 0.79 | MEN1 (0.46) | ALDH1A1SMN1; SMN2HTTMAPTCYP1A2 | |
| SCHEMBL862236 | 0.73 | NPC1 (0.54) | ALDH1A1SMN1; SMN2HTTMAPTKDM4E | |
| SCHEMBL28811930 | 0.73 | KDM4E (0.54) | ALDH1A1MAPTKDM4ESYKATAD2 | |
| SCHEMBL18743547 | 0.73 | MAPT (0.54) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL27883837 | 0.72 | KDM4E (0.39) | MAPTKDM4ESYKNR4A2 | |
| SCHEMBL8654916 | 0.72 | CCR1 (0.61) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL17173759 | 0.72 | KDM4E (0.52) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL20278460 | 0.71 | MAPT (0.52) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL15233158 | 0.70 | SYK (0.56) | ALDH1A1LMNAMAPTKDM4ESYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3318561-B1 | HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC (US) | 2021-12-22 | — | — | EP | disclosed |
| EP-2576540-B1 | HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC (US) | 2019-09-04 | — | — | EP | disclosed |
| EP-3318561-A1 | HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | Sunovion Pharmaceuticals Inc. (US) | 2018-05-09 | — | — | EP | disclosed |