Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.35 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25553737 | 0.86 | HTT (0.42) | SMN1; SMN2HRH4KMT2AMAPTTSHR | |
| SCHEMBL18902116 | 0.83 | TAAR1 (0.38) | KCNH2MAPTRPS6KA3 | |
| SCHEMBL18902056 | 0.82 | KDM4E (0.35) | MAPTTSHR | |
| SCHEMBL25025841 | 0.82 | TRPV3 (0.37) | — | |
| SCHEMBL30233815 | 0.82 | TRPV3 (0.37) | — | |
| SCHEMBL25025740 | 0.81 | SCN10A (0.37) | SMN1; SMN2KMT2AMAPTTSHRMEN1 | |
| SCHEMBL24309237 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2HRH4KMT2AMAPTTSHR | |
| SCHEMBL18334275 | 0.77 | SMN1; SMN2 (0.53) | SMN1; SMN2HRH4KMT2AMAPTTSHR | |
| SCHEMBL18901953 | 0.77 | KIT (0.37) | HRH4 | |
| SCHEMBL14070979 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2HRH4KCNH2HRH3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3173411-B1 | TRPV1 ANTAGONISTS INCLUDING DIHYDROXY SUBSTITUENT AND USES THEREOF | PURDUE PHARMA LP (US) | 2018-05-09 | — | — | EP | disclosed |