SCHEMBL2012487

SCHEMBL2012487

CN(C(=O)c1cccc2ncccc12)C(CCNC(=O)c1cccn1C)Cc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.61
HCRTR2 O43614 2/20 0.61
NSD2 O96028 1/20 0.46
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45
PADI4 Q9UM07 3/20 0.39
ALDH1A1 P00352 2/20 0.38
PSMB5 P28074 1/20 0.36
DRD2 P14416 1/20 0.36
DRD3 P35462 1/20 0.36
MEN1 O00255 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
KMT2A Q03164 1/20 0.36
POLR1A O95602 1/20 0.36
HRH3 Q9Y5N1 1/20 0.35
CTSV O60911 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2054308 0.95 HCRTR1 (0.60) HCRTR1HCRTR2NSD2NPC1RAB9A
SCHEMBL2011844 0.95 HCRTR1 (0.60) HCRTR1HCRTR2NSD2NPC1RAB9A
SCHEMBL2017423 0.89 HCRTR1 (0.62) HCRTR1HCRTR2NSD2NPC1RAB9A
SCHEMBL2015191 0.88 HCRTR1 (0.62) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2012888 0.87 HCRTR1 (0.62) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2015844 0.87 HCRTR1 (0.62) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2013911 0.87 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2019473 0.87 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2016933 0.86 HCRTR1 (0.60) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2017894 0.86 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO claimed
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO disclosed