SCHEMBL2016933

SCHEMBL2016933

CN(C(=O)c1c[nH]c2ncccc12)C(CCNC(=O)c1cccn1C)Cc1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.60
HCRTR2 O43614 2/20 0.60
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45
ADORA2A P29274 1/20 0.43
PADI4 Q9UM07 3/20 0.41
LATS1 O95835 1/20 0.39
LATS2 Q9NRM7 1/20 0.39
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
HDAC1 Q13547 2/20 0.38
HDAC6 Q9UBN7 2/20 0.38
MAP2K1 Q02750 1/20 0.37
CCNE1 P24864 1/20 0.37
CDK2 P24941 1/20 0.37
HRH3 Q9Y5N1 2/20 0.37
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2011985 0.89 HCRTR1 (0.58) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2054164 0.88 HCRTR1 (0.61) HCRTR1HCRTR2NPC1RAB9A
SCHEMBL2011905 0.88 HCRTR1 (0.61) HCRTR1HCRTR2NPC1RAB9A
SCHEMBL2013911 0.86 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2012487 0.86 HCRTR1 (0.61) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2015191 0.85 HCRTR1 (0.62) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2054308 0.84 HCRTR1 (0.60) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2011844 0.84 HCRTR1 (0.60) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2015844 0.83 HCRTR1 (0.62) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2012888 0.83 HCRTR1 (0.62) HCRTR1HCRTR2NPC1RAB9APADI4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO disclosed