Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011832 | 0.91 | L3MBTL1 (0.50) | MAPTSMN1; SMN2HTTALDH1A1TSHR | |
| SCHEMBL2012009 | 0.90 | MAPT (0.46) | MAPTSMN1; SMN2HTTALDH1A1TSHR | |
| SCHEMBL2015402 | 0.88 | AKR1C3 (0.43) | MAPTSMN1; SMN2HTTALDH1A1KDM4E | |
| SCHEMBL2013896 | 0.88 | MAPT (0.52) | MAPTSMN1; SMN2HTTALDH1A1GAA | |
| SCHEMBL2017795 | 0.87 | MEN1 (0.52) | MAPTSMN1; SMN2HTTALDH1A1CYP3A4 | |
| SCHEMBL2016546 | 0.85 | KDM4E (0.53) | MAPTSMN1; SMN2HTTALDH1A1HSD17B10 | |
| SCHEMBL2014194 | 0.83 | L3MBTL1 (0.48) | MAPTSMN1; SMN2HTTALDH1A1GAA | |
| SCHEMBL2163234 | 0.83 | MAPT (0.54) | MAPTSMN1; SMN2HTTALDH1A1GAA | |
| SCHEMBL2017422 | 0.82 | MAPT (0.43) | MAPTSMN1; SMN2HTTALDH1A1GAA | |
| SCHEMBL2163396 | 0.82 | MAPT (0.54) | MAPTSMN1; SMN2HTTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |