Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.63 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | PDE5A | O76074 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2090887 | 0.86 | AMY1A (0.63) | AMY1ASLC2A1ALOX5EPHX2NPC1 | |
| SCHEMBL15643913 | 0.86 | SMN1; SMN2 (0.64) | AMY1ASLC2A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3332738 | 0.84 | AMY1A (0.67) | AMY1ASLC2A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2096956 | 0.83 | AMY1A (0.76) | AMY1ASLC2A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31027930 | 0.83 | AMY1A (0.76) | AMY1ASLC2A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15829537 | 0.82 | AMY1A (0.59) | AMY1ASLC2A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4117255 | 0.82 | NPC1 (0.71) | AMY1ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3932091 | 0.81 | AMY1A (0.57) | AMY1ASLC2A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27072943 | 0.80 | AMY1A (0.59) | AMY1ASLC2A1ALOX5EPHX2NPC1 | |
| SCHEMBL16142437 | 0.79 | F2 (0.62) | AMY1ANPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3318557-A2 | QUINOLONE COMPOUND | Otsuka Pharmaceutical Co., Ltd. (JP) | 2018-05-09 | — | — | EP | disclosed |