Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18531113 | 1.00 | TDP1 (0.43) | TDP1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4464586 | 0.87 | TDP1 (0.44) | TDP1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL15247429 | 0.84 | TDP1 (0.42) | TDP1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9721607 | 0.82 | AOC3 (0.50) | ALDH1A1GLA | |
| SCHEMBL334612 | 0.79 | KMT2A (0.38) | TDP1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5495958 | 0.78 | TDP1 (0.45) | TDP1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL52157 | 0.77 | TAAR1 (0.53) | TDP1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3117376 | 0.76 | TDP1 (0.44) | TDP1CHRM2CHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL19405689 | 0.75 | TDP1 (0.42) | TDP1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL51950 | 0.74 | TAAR1 (0.55) | TDP1CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491926-B1 | Treatment of protein degradation disorders | HARVARD COLLEGE (US) | 2018-05-09 | — | — | EP | disclosed |