Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20125070 | 0.87 | TDP1 (0.43) | TDP1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL18531113 | 0.87 | TDP1 (0.43) | TDP1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL15247429 | 0.85 | TDP1 (0.42) | TDP1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL10643254 | 0.81 | MAPT (0.37) | TDP1ALDH1A1TSHRTP53CYP3A4 | |
| SCHEMBL9827001 | 0.81 | AOC3 (0.37) | CYP3A4 | |
| SCHEMBL5495958 | 0.79 | TDP1 (0.45) | TDP1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9826255 | 0.79 | PKM (0.43) | TDP1ALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL3117376 | 0.78 | TDP1 (0.44) | TDP1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3901257 | 0.78 | ALDH1A1 (0.35) | ALDH1A1MGLL | |
| SCHEMBL334612 | 0.77 | KMT2A (0.38) | TDP1CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582355-B2 | Optical unit using plastic lenses | FUJIFILM CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| EP-1802598-A2 | ASYMMETRIC SYNTHESIS OF DIHYDROBENZOFURAN DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006047288-A2 | ASYMMETRIC SYNTHESIS OF DIHYDROBENZOFURAN DERIVATIVES | WYETH (US) | 2006-05-04 | — | — | WO | disclosed |
| US-20060089405-A1 | Asymmetric synthesis of dihydrobenzofuran derivatives | WYETH (US) | 2006-04-27 | — | — | US | disclosed |
| US-20060046065-A1 | Optical unit using plastic lenses | FUJI PHOTO FILM CO., LTD. | 2006-03-02 | — | — | US | disclosed |
| EP-0596586-B1 | Process for the production of metal complexes of N-beta-hydroxalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and derivatives thereof | SCHERING AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5410043-A | Chemical intermediate for metal complexes | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-04-25 | — | — | US | disclosed |
| EP-0596586-A1 | Process for the production of metal complexes of N-beta-hydroxalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and derivatives thereof | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-05-11 | — | — | EP | disclosed |
| EP-0022371-B1 | SUBSTITUTED PIPERAZINES AND PIPERIDINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1983-01-19 | — | — | EP | disclosed |
| US-4357332-A | 1-BENZYL-4-/2-HYDROXY-3-BENZYLOXYPROPYL/PIPERAZINES | PFIZER INC. (US) | 1982-11-02 | — | — | US | disclosed |
| EP-0022371-A1 | Substituted piperazines and piperidines and pharmaceutical compositions containing them | PFIZER INC. (US) | 1981-01-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089405-A1 | Asymmetric synthesis of dihydrobenzofuran derivatives | DHFR, DHODH, DPYD | TDP1 2506/4885CHRM2 3710/4885CHRM4 4443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.