Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 7/20 | 0.59 |
| ▸ | KDM5A | P29375 | 6/20 | 0.59 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | YTHDF2 | Q9Y5A9 | 2/20 | 0.34 |
| ▸ | YTHDF3 | Q7Z739 | 1/20 | 0.34 |
| ▸ | YTHDF1 | Q9BYJ9 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 3/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20125337 | 0.94 | KDM5B (0.61) | KDM5BKDM5ACCR1CCR5CCR8 | |
| SCHEMBL15652643 | 0.76 | IKBKB (0.46) | CCR1CCR5CCR8IKBKBCHUK | |
| SCHEMBL16157369 | 0.75 | KDM5B (1.00) | KDM5BKDM5AKDM4CKDM4A | |
| SCHEMBL20125267 | 0.72 | KDM5B (0.65) | KDM5BKDM5AKDM4CNPY5RKDM4A | |
| SCHEMBL30430250 | 0.71 | KDM5A (0.38) | KDM5BKDM5AYTHDF2YTHDF3YTHDF1 | |
| SCHEMBL20125363 | 0.71 | KDM5B (0.60) | KDM5BKDM5AKDM4CKDM4A | |
| SCHEMBL16149862 | 0.71 | KDM5A (0.71) | KDM5BKDM5AKDM4CKDM4APDK2 | |
| SCHEMBL21204922 | 0.70 | KDM5A (0.32) | KDM5BKDM5A | |
| SCHEMBL16150053 | 0.70 | KDM5B (1.00) | KDM5BKDM5AKDM4CKDM4A | |
| SCHEMBL20125330 | 0.69 | KDM5B (0.62) | KDM5BKDM5ACCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968282-B1 | HISTONE DEMENTHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2018-05-09 | — | — | EP | disclosed |