Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.64 |
| ▸ | KDM4A | O75164 | 1/20 | 0.64 |
| ▸ | KDM5A | P29375 | 5/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20125360 | 0.91 | KDM4C (0.65) | KDM4CKDM4AKDM5AKDM5BKDM4E | |
| SCHEMBL20125370 | 0.89 | KDM5A (0.62) | KDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL20125475 | 0.88 | KDM5A (0.56) | KDM4CKDM4AKDM5AKDM5BKDM4E | |
| SCHEMBL20125476 | 0.86 | KDM4C (0.70) | KDM4CKDM4AKDM5AKDM5BKDM4E | |
| SCHEMBL20125349 | 0.78 | KDM4C (0.58) | KDM4CKDM4AKDM5AKDM5BKDM4E | |
| SCHEMBL16149068 | 0.78 | KDM4C (1.00) | KDM4CKDM4AKDM5AKDM5B | |
| SCHEMBL16150547 | 0.77 | KDM4C (0.82) | KDM4CKDM4AKDM5AKDM5BKDM4E | |
| SCHEMBL19231060 | 0.74 | KDM4A (0.62) | KDM4CKDM4AKDM5APKMFGFR2 | |
| SCHEMBL20125325 | 0.70 | KDM4C (0.60) | KDM4CKDM5AKDM5BKDM4EMAPK1 | |
| SCHEMBL6791147 | 0.66 | KDM4A (0.51) | KDM4CKDM4AKDM4EPKMFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968282-B1 | HISTONE DEMENTHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2018-05-09 | — | — | EP | disclosed |