Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.77 |
| ▸ | KDM5A | P29375 | 2/20 | 0.77 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.77 |
| ▸ | PROKR1 | Q8TCW9 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16151100 | 0.87 | KDM4C (1.00) | KDM4CKDM5AKDM5BPROKR1ALDH1A1 | |
| SCHEMBL20125439 | 0.85 | KDM4C (0.75) | KDM4CKDM5AKDM5BPROKR1ALDH1A1 | |
| SCHEMBL16149743 | 0.83 | KDM4C (0.81) | KDM4CKDM5AKDM5BPROKR1ALDH1A1 | |
| SCHEMBL16149299 | 0.82 | KDM4C (1.00) | KDM4CKDM5AKDM5BPROKR1 | |
| SCHEMBL20125440 | 0.78 | KDM4C (0.72) | KDM4CKDM5AKDM5BPROKR1ALDH1A1 | |
| SCHEMBL16150318 | 0.78 | KDM4C (0.80) | KDM4CKDM5AKDM5BPROKR1 | |
| SCHEMBL16157351 | 0.69 | KDM5A (0.97) | KDM4CKDM5AKDM5BTP53MAPT | |
| SCHEMBL16445744 | 0.68 | PROKR1 (1.00) | PROKR1 | |
| SCHEMBL16148830 | 0.68 | KDM5A (1.00) | KDM4CKDM5AKDM5BTP53MAPT | |
| SCHEMBL20074605 | 0.67 | KDM5A (0.54) | KDM4CKDM5AKDM5BPROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968282-B1 | HISTONE DEMENTHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2018-05-09 | — | — | EP | disclosed |