Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.72 |
| ▸ | KDM5A | P29375 | 2/20 | 0.66 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SCD5 | Q86SK9 | 5/20 | 0.46 |
| ▸ | SCD | O00767 | 2/20 | 0.45 |
| ▸ | RBP4 | P02753 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16149299 | 0.84 | KDM4C (1.00) | KDM4CKDM5AKDM5BRAB9ASCD5 | |
| SCHEMBL16150318 | 0.80 | KDM4C (0.80) | KDM4CKDM5AKDM5BRAB9ASCD5 | |
| SCHEMBL16151100 | 0.79 | KDM4C (1.00) | KDM4CKDM5AKDM5BPROKR1MAPT | |
| SCHEMBL20125366 | 0.78 | KDM4C (0.77) | KDM4CKDM5AKDM5BPROKR1MAPT | |
| SCHEMBL20125439 | 0.78 | KDM4C (0.75) | KDM4CKDM5AKDM5BPROKR1MAPT | |
| SCHEMBL16149743 | 0.76 | KDM4C (0.81) | KDM4CKDM5AKDM5BPROKR1MAPT | |
| SCHEMBL20125329 | 0.69 | KDM4C (0.71) | KDM4CKDM5AKDM5BMAPT | |
| SCHEMBL12447335 | 0.67 | RAB9A (0.72) | RAB9ASCD5SCDPROKR1NPC1 | |
| SCHEMBL24112555 | 0.66 | HRH4 (0.63) | KDM4CRAB9ANPC1ATMMAPT | |
| SCHEMBL25770224 | 0.66 | HRH4 (0.63) | KDM4CRAB9ANPC1ATMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968282-B1 | HISTONE DEMENTHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2018-05-09 | — | — | EP | disclosed |