Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 7/20 | 0.68 |
| ▸ | KDM5A | P29375 | 4/20 | 0.68 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.44 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20125334 | 0.99 | KDM4C (0.66) | KDM4CKDM5AKDM5BMAPTLMNA | |
| SCHEMBL20125439 | 0.82 | KDM4C (0.75) | KDM4CKDM5AKDM5BMAPTLMNA | |
| SCHEMBL16148830 | 0.81 | KDM5A (1.00) | KDM4CKDM5AKDM5BMAPTLMNA | |
| SCHEMBL16157351 | 0.80 | KDM5A (0.97) | KDM4CKDM5AKDM5BMAPTLMNA | |
| SCHEMBL20125271 | 0.79 | KDM4C (0.72) | KDM4CKDM5AKDM5BHRH4 | |
| SCHEMBL16150308 | 0.77 | KDM4C (0.74) | KDM4CKDM5AKDM5BMAPTLMNA | |
| SCHEMBL20125377 | 0.77 | KDM4C (0.73) | KDM4CKDM5AKDM5BMAPTHPGD | |
| SCHEMBL4268287 | 0.73 | MAPT (0.60) | KDM4CKDM5AKDM5BMAPTLMNA | |
| SCHEMBL16157398 | 0.68 | KDM5A (0.74) | KDM4CKDM5AKDM5B | |
| SCHEMBL20125363 | 0.67 | KDM5B (0.60) | KDM4CKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968282-B1 | HISTONE DEMENTHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2018-05-09 | — | — | EP | disclosed |