Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.34 |
| ▸ | CA2 | P00918 | 4/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14457193 | 0.78 | CA1 (0.38) | CA1CA2CA12CA9 | |
| SCHEMBL13328191 | 0.73 | CA1 (0.36) | CA1CA2CA12CA9 | |
| SCHEMBL17378886 | 0.72 | — | — | |
| SCHEMBL19909890 | 0.72 | KDM4E (0.31) | — | |
| SCHEMBL19240692 | 0.72 | JAK3 (0.49) | JAK3JAK1 | |
| SCHEMBL19240687 | 0.72 | JAK3 (0.49) | JAK3JAK1 | |
| SCHEMBL19240693 | 0.72 | JAK3 (0.49) | JAK3JAK1 | |
| SCHEMBL28206408 | 0.72 | CA1 (0.46) | CA1CA2CA12CA9 | |
| SCHEMBL24244429 | 0.71 | JAK3 (0.48) | JAK3CA1CA2CA12CA9 | |
| SCHEMBL20962117 | 0.70 | ALDH1A1 (0.33) | CA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3318565-A1 | PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYRROLO[2,3-D]PYRIDINYL ACRYLAMIDES | Pfizer Inc (US) | 2018-05-09 | — | — | EP | disclosed |