SCHEMBL2012646

SCHEMBL2012646

Cc1cc(C(=O)N(C)C(CCNC(=O)c2cccn2C)Cc2ccccc2)cc(N2CCCC2)n1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.60
HCRTR2 O43614 2/20 0.60
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
NAPEPLD Q6IQ20 5/20 0.37
GBA1 P04062 1/20 0.37
SLC2A1 P11166 2/20 0.37
MEN1 O00255 2/20 0.36
ALDH1A1 P00352 2/20 0.36
KMT2A Q03164 2/20 0.36
TACR2 P21452 1/20 0.36
TACR1 P25103 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
HTT P42858 1/20 0.36
HRH3 Q9Y5N1 1/20 0.36
HTR1A P08908 1/20 0.36
HTR2A P28223 1/20 0.36
DRD3 P35462 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2011910 0.90 HCRTR1 (0.69) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2017217 0.86 HCRTR1 (0.64) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2014068 0.85 HCRTR1 (0.65) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2053613 0.85 HCRTR1 (0.63) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2010845 0.85 HCRTR1 (0.63) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2016237 0.85 HCRTR1 (0.64) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2054319 0.85 HCRTR1 (0.64) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2010949 0.83 HCRTR1 (0.72) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL6919382 0.83 HCRTR1 (0.72) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL13139102 0.83 HCRTR1 (0.71) HCRTR1HCRTR2NPC1RAB9AHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO claimed
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO disclosed