SCHEMBL2012839

SCHEMBL2012839

CN(C(=O)c1nn(C)c2ccccc12)C(CCNC(=O)c1cccn1C)Cc1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.59
HCRTR2 O43614 2/20 0.59
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
HTR3A P46098 3/20 0.41
KDM4E B2RXH2 2/20 0.41
ALDH1A1 P00352 1/20 0.40
CYP3A4 P08684 1/20 0.40
TSHR P16473 1/20 0.40
MAPK1 P28482 1/20 0.40
HSD17B10 Q99714 1/20 0.40
HTR3E A5X5Y0 2/20 0.40
HTR3B O95264 2/20 0.40
HTR3D Q70Z44 2/20 0.40
HTR3C Q8WXA8 2/20 0.40
PADI4 Q9UM07 2/20 0.39
SLC22A2 O15244 1/20 0.39
CHRNB2 P17787 1/20 0.39
CHRNA3 P32297 1/20 0.39
CHRNA4 P43681 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2013351 0.88 HCRTR1 (0.58) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2013812 0.86 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9AKDM4E
SCHEMBL2015468 0.85 HCRTR1 (0.58) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2051271 0.84 HCRTR1 (0.61) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2012147 0.84 HCRTR1 (0.61) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2054339 0.84 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2054337 0.84 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2012754 0.83 HCRTR1 (0.62) HCRTR1HCRTR2NPC1RAB9AALDH1A1
SCHEMBL2014186 0.83 HCRTR1 (0.60) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL13139060 0.83 HCRTR1 (0.77) HCRTR1HCRTR2NPC1RAB9APADI4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO claimed
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO disclosed