Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.61 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2051271 | 1.00 | HCRTR1 (0.61) | HCRTR1HCRTR2NPC1RAB9ABCHE | |
| SCHEMBL2011272 | 0.90 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9ABCHE | |
| SCHEMBL2013911 | 0.87 | HCRTR1 (0.59) | HCRTR1HCRTR2NPC1RAB9AHDAC1 | |
| SCHEMBL2015001 | 0.86 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9ABCHE | |
| SCHEMBL13139060 | 0.85 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9AHDAC1 | |
| SCHEMBL2011054 | 0.84 | HCRTR1 (0.57) | HCRTR1HCRTR2NPC1RAB9AHDAC1 | |
| SCHEMBL2012839 | 0.84 | HCRTR1 (0.59) | HCRTR1HCRTR2NPC1RAB9AALDH1A1 | |
| SCHEMBL2054164 | 0.84 | HCRTR1 (0.61) | HCRTR1HCRTR2NPC1RAB9AACHE | |
| SCHEMBL2014119 | 0.84 | HCRTR1 (0.59) | HCRTR1HCRTR2NPC1RAB9AHDAC1 | |
| SCHEMBL2011905 | 0.84 | HCRTR1 (0.61) | HCRTR1HCRTR2NPC1RAB9AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |