Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.48 |
| ▸ | FOS | P01100 | 2/20 | 0.48 |
| ▸ | TTR | P02766 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5018935 | 0.83 | PNMT (0.70) | PNMTMEN1ALDH1A1TP53KMT2A | |
| SCHEMBL20061665 | 0.82 | PNMT (0.46) | PNMTALOX15ALOX12MEN1ALDH1A1 | |
| SCHEMBL10599873 | 0.81 | PNMT (0.68) | PNMTALOX15ALOX12MEN1ALDH1A1 | |
| SCHEMBL17407613 | 0.80 | PNMT (0.72) | PNMTSLC6A2SLC6A3POLBIDO1 | |
| SCHEMBL15384319 | 0.80 | PNMT (0.61) | PNMTMEN1ALDH1A1TP53KMT2A | |
| SCHEMBL3058411 | 0.79 | PNMT (1.00) | PNMTSLC6A2SLC6A3HTR2AHTR2B | |
| SCHEMBL20353176 | 0.79 | PNMT (0.66) | PNMTALOX15MEN1ALDH1A1TP53 | |
| SCHEMBL2424621 | 0.79 | PNMT (0.66) | PNMTALOX15SLC6A2SLC6A3POLB | |
| SCHEMBL3058413 | 0.79 | PNMT (1.00) | PNMTSLC6A2SLC6A3HTR2AHTR2B | |
| SCHEMBL17413477 | 0.79 | PNMT (1.00) | PNMTSLC6A2SLC6A3HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180127402-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | CELLCENTRIC LTD (GB) | 2018-05-10 | — | — | US | disclosed |
| US-20180127402-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | CELLCENTRIC LTD (GB) | 2018-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127402-A1 | ISOXAZOLYL SUBSTITUTED BENZIMIDAZOLES | EP300, HDAC3, HDAC1 | PNMT 3789/4885ALOX15 4701/4885ALOX12 4667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.