Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.59 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012888 | 0.89 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2015844 | 0.89 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2017008 | 0.89 | HCRTR1 (0.56) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2053397 | 0.89 | HCRTR1 (0.55) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2016967 | 0.89 | HCRTR1 (0.55) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2011240 | 0.88 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2054318 | 0.88 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2054419 | 0.87 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2013457 | 0.87 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2010539 | 0.85 | HCRTR1 (0.63) | HCRTR1HCRTR2NPC1RAB9APADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |