SCHEMBL2012936

SCHEMBL2012936

C[Si](C)(C)C#Cc1ccccc1C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.46
ALOX15 P16050 1/20 0.46
KDM4E B2RXH2 5/20 0.45
HPGD P15428 3/20 0.45
TSHR P16473 3/20 0.45
MAPT P10636 2/20 0.45
HSD17B10 Q99714 2/20 0.45
MEN1 O00255 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
KMT2A Q03164 1/20 0.45
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
CA12 O43570 3/20 0.41
CA1 P00915 3/20 0.41
CA2 P00918 3/20 0.41
CA4 P22748 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28728276 0.85 FFAR1 (0.47) ALDH1A1ALOX15KDM4EHPGDTSHR
SCHEMBL3644022 0.84 AKR1C3 (0.47) ALDH1A1KDM4EHPGDTSHRMAPT
SCHEMBL19813902 0.84 NPC1 (0.59) ALDH1A1KDM4EHPGDTSHRMAPT
SCHEMBL29409566 0.82 ALDH1A1 (0.62) ALDH1A1ALOX15KDM4EHPGDTSHR
SCHEMBL69321 0.82 ALDH1A1 (0.62) ALDH1A1ALOX15KDM4EHPGDTSHR
SCHEMBL18946128 0.81 MEN1 (0.45) ALDH1A1KDM4EHPGDTSHRMAPT
SCHEMBL497720 0.81 TSHR (0.49) ALDH1A1ALOX15KDM4EHPGDTSHR
SCHEMBL28756104 0.81 ALDH1A1 (0.42) ALDH1A1ALOX15KDM4EHPGDTSHR
SCHEMBL576637 0.79 ALDH1A1 (0.52) ALDH1A1ALOX15KDM4EHPGDTSHR
SCHEMBL3839029 0.77 KDM4E (0.49) ALDH1A1ALOX15KDM4EHPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023210599-A1 COMPOUND SERVING AS DDR1 KINASE INHIBITOR, AND MEDICINE 日本新薬株式会社 2023-11-02 WO disclosed
EP-4192816-A1 COMPOUNDS AS C5AR INHIBITORS Kira Pharmaceuticals (Suzhou) Ltd. (CN) 2023-06-14 EP disclosed
EP-3538088-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS 3-V Biosciences, Inc. (US) 2019-09-18 EP disclosed
WO-2018089904-A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS 3-V BIOSCIENCES, INC. (US) 2018-05-17 WO disclosed
WO-2017192304-A1 ARYLCARBOXAMIDES AND USES THEREOF INCEPTION 1, INC. (US) 2017-11-09 WO disclosed
EP-2935211-A1 INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS Actelion Pharmaceuticals Ltd. (CH) 2015-10-28 EP disclosed
WO-2014097140-A1 INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2014-06-26 WO disclosed
EP-2230238-B1 INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT LG LIFE SCIENCES LTD (KR) 2013-12-11 EP disclosed
WO-2011075630-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION (US) 2011-06-23 WO disclosed
EP-2230238-A2 INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT LG Life Sciences Ltd. (KR) 2010-09-22 EP disclosed
WO-2002035580-A2 THREE-TERMINAL FIELD-CONTROLLED MOLECULAR DEVICES MOLECULAR ELECTRONICS CORPORATION (US) 2002-05-02 WO disclosed